Mac and Cheese Meatloaf Casserole
Mac and Cheese Meatloaf Casserole is a delightful fusion of flavors that brings together the comforting familiarity of meatloaf and the creamy goodness of macaroni and cheese. This dish serves as the perfect centerpiece for family dinners, potlucks, or any occasion where you want to impress your guests with minimal effort. The combination of ground beef and cheesy pasta creates a hearty meal everyone will love.
Why You’ll Love This Recipe
- Comforting and Satisfying: This casserole combines two beloved classics into one fulfilling dish.
- Easy Preparation: With straightforward steps, this recipe is perfect for cooks of all skill levels.
- Versatile: You can customize it by adding your favorite vegetables or spices to make it your own.
- Family-Friendly: Kids and adults alike will enjoy this flavorful twist on traditional meatloaf.
- Make Ahead: This casserole can be prepared in advance, making it an excellent option for busy weeknights.
Tools and Preparation
Before diving into the recipe, gather your tools to ensure a smooth cooking experience. Having the right equipment makes the process easier and more enjoyable.
Essential Tools and Equipment
- Mixing bowls
- Measuring cups and spoons
- Ziploc bag
- Rolling pin
- 9 x 13 inch baking dish
- Whisk
Importance of Each Tool
- Mixing bowls: Essential for combining ingredients evenly without any mess.
- Ziploc bag: Perfect for crushing crackers quickly without creating a mess in your kitchen.
- Whisk: Helps achieve a smooth consistency when mixing liquids like milk and soup.

Ingredients
To create this delicious Mac and Cheese Meatloaf Casserole, you’ll need the following ingredients:
For the Meatloaf Base
- 1 cup ketchup
- 1 cup Sweet Baby Ray’s Hickory & Brown Sugar barbecue sauce
- 2 lbs lean ground beef
- 30 Ritz Crackers
- 2 oz Lipton onion soup mix
- 2 eggs
For the Macaroni Topping
- 3 cups macaroni noodles
- 2 cups milk
- 10.5 oz condensed cheddar cheese soup
- 1 teaspoon salt
- 1 teaspoon pepper
- 1 tablespoon garlic powder
- 1 tablespoon onion powder
- 4 cups shredded mozzarella and cheddar cheese blend
How to Make Mac and Cheese Meatloaf Casserole
Step 1: Preheat the Oven
Preheat your oven to 350°F (175°C) to prepare for baking.
Step 2: Prepare the Ketchup Mixture
- In a medium mixing bowl, combine the ketchup and barbecue sauce.
- Stir until well mixed, then set aside.
Step 3: Combine Meatloaf Ingredients
- In a large mixing bowl, add the ground beef.
- Crush the Ritz crackers in a Ziploc bag using a rolling pin until fine crumbs form.
- Pour the cracker crumbs into the bowl with the ground beef.
- Add the onion soup mix and eggs to this mixture.
- Pour in ½ cup of the ketchup mixture from earlier.
Step 4: Mix It All Together
Use your hands to combine all ingredients until fully mixed.
Step 5: Form and Bake Meatloaf
- Transfer the meatloaf mixture into a greased 9 x 13 inch baking dish.
- Press it out evenly across the dish.
- Spread the remaining ketchup mixture over the top of the meatloaf.
- Bake for 30 minutes.
Step 6: Cook Macaroni Noodles
While baking, cook macaroni noodles according to package instructions; then drain them well.
Step 7: Prepare Macaroni Mixture
- In a large mixing bowl, pour in milk and cheddar cheese soup.
- Whisk until no lumps remain.
- Add salt, pepper, garlic powder, and onion powder; whisk again until combined.
Step 8: Combine Macaroni with Cheese Mixture
Add cooked macaroni noodles to this bowl and stir until coated with sauce. Then add 2 cups of shredded cheese, stirring well again.
Step 9: Layer Macaroni on Meatloaf
After baking for 30 minutes:
1. Remove meatloaf from oven.
2. Pour macaroni mixture on top evenly.
3. Sprinkle remaining shredded cheese on top.
Step 10: Final Bake
Return dish to oven; bake until cheese is melted and slightly browned (about 17-20 minutes).
Step 11: Serve
Let casserole sit for a few minutes before slicing and serving hot!
Enjoy your delicious Mac and Cheese Meatloaf Casserole!
How to Serve Mac and Cheese Meatloaf Casserole
Serving Mac and Cheese Meatloaf Casserole can be both fun and versatile. This hearty dish pairs well with various sides or can be enjoyed on its own for a filling meal. Here are some great serving ideas to elevate your dining experience.
Casual Family Dinner
- Serve the casserole straight from the baking dish, allowing everyone to help themselves. Accompany it with a simple green salad for a refreshing contrast.
Game Night Delight
- Slice the casserole into squares and serve alongside finger foods like veggies and dip. This creates a casual atmosphere perfect for entertaining guests.
Comfort Food Feast
- For a cozy night in, pair the casserole with warm bread rolls and butter. This combination brings warmth and comfort to any meal.
Meal Prep Option
- Portion out the casserole into individual containers for easy lunches throughout the week. It reheats beautifully, making it an ideal meal prep choice.
How to Perfect Mac and Cheese Meatloaf Casserole
To ensure your Mac and Cheese Meatloaf Casserole turns out perfectly every time, consider these helpful tips.
- Use lean ground beef: Opt for lean ground beef to keep the casserole moist without excess fat.
- Don’t overcook pasta: Cook macaroni noodles al dente so they don’t become mushy when baked with the meatloaf.
- Let it rest: Allow the casserole to sit for a few minutes after baking to help it set before slicing.
- Mix cheeses: Combine mozzarella and cheddar cheeses for a rich flavor profile that melts beautifully.
- Experiment with spices: Feel free to add herbs like parsley or thyme for added depth of flavor.
- Try different sauces: Substitute barbecue sauce with a homemade sauce for a unique twist on classic flavors.
Best Side Dishes for Mac and Cheese Meatloaf Casserole
Pairing side dishes with Mac and Cheese Meatloaf Casserole can enhance your meal experience. Here are some delicious options to consider.
- Garlic Bread: Toasted bread topped with garlic butter adds a crunchy texture that complements the creamy casserole.
- Steamed Broccoli: Lightly steamed broccoli provides a nutritious side that balances the richness of the casserole.
- Coleslaw: A tangy coleslaw adds crunch and freshness, making it an excellent accompaniment.
- Roasted Vegetables: Seasonal roasted vegetables bring color, flavor, and nutrition to your plate.
- Caesar Salad: Crisp romaine lettuce with Caesar dressing gives a nice crunch that contrasts well with the casserole’s texture.
- Corn on the Cob: Sweet corn is always a crowd-pleaser; grill or boil it for a classic side dish.
- Baked Beans: Sweet baked beans provide additional protein and sweetness that pairs nicely with savory flavors.
- Potato Wedges: Crispy potato wedges are fun finger food that adds heartiness to your meal.
Common Mistakes to Avoid
When preparing your Mac and Cheese Meatloaf Casserole, it’s easy to make some common mistakes. Here are a few to watch out for:
- Incorrect Meat Ratio: Using too much or too little ground beef can affect texture. Ensure you use the recommended 2 lbs for optimal results.
- Overcooking Pasta: Cooking macaroni noodles too long can lead to mushiness. Follow package instructions closely for al dente pasta.
- Neglecting Seasoning: Forgetting to season the meatloaf mixture may result in bland flavors. Always follow the seasoning measurements for rich taste.
- Skipping Rest Time: Cutting into the casserole immediately after baking can lead to a messy serving. Let it sit for a few minutes before slicing to set properly.
- Not Greasing the Dish: Failing to grease your baking dish could mean a stuck casserole. Always use a non-stick spray or oil the dish generously.

Storage & Reheating Instructions
Refrigerator Storage
- Store leftovers in an airtight container.
- It will keep well in the fridge for up to 3-4 days.
Freezing Mac and Cheese Meatloaf Casserole
- Wrap tightly in plastic wrap and aluminum foil before freezing.
- It can be frozen for up to 2-3 months for best quality.
Reheating Mac and Cheese Meatloaf Casserole
- Oven: Preheat your oven to 350°F. Cover with foil and heat for about 25-30 minutes until warmed through.
- Microwave: Place on a microwave-safe plate, cover, and heat in short increments until hot, stirring occasionally.
- Stovetop: Heat on medium-low heat in a skillet, stirring frequently until heated through.
Frequently Asked Questions
If you have questions about making Mac and Cheese Meatloaf Casserole, you’re not alone! Here are some common inquiries.
Can I use chicken instead of beef in Mac and Cheese Meatloaf Casserole?
Yes, you can substitute ground chicken or turkey for the beef. Adjust seasonings as needed.
How do I prevent my casserole from being dry?
Make sure not to overbake your meatloaf base. Properly incorporating moisture-rich ingredients like milk and soup helps maintain juiciness.
Can I add vegetables to my casserole?
Absolutely! Feel free to incorporate cooked vegetables like spinach or bell peppers into the macaroni mix for added nutrition.
Is Mac and Cheese Meatloaf Casserole freezer-friendly?
Yes, it freezes well! Just ensure it’s wrapped tightly before freezing.
Final Thoughts
Mac and Cheese Meatloaf Casserole is a delightful fusion of comfort foods that offers versatility in flavors and ingredients. You can customize it by adding different cheeses or veggies based on what you have available. We encourage you to try this hearty dish at your next family dinner!
Mac and Cheese Meatloaf Casserole
Mac and Cheese Meatloaf Casserole is a delightful twist on two classic comfort foods, combining the rich flavors of a hearty meatloaf with the creamy goodness of macaroni and cheese. This dish is perfect for family dinners, potlucks, or any occasion where you want to impress without spending hours in the kitchen. With tender ground beef layered under a cheesy pasta topping, it promises to satisfy even the pickiest eaters. Plus, it’s customizable—feel free to add your favorite vegetables or spices!
- Prep Time: 20 minutes
- Cook Time: 50 minutes
- Total Time: 1 hour 10 minutes
- Yield: Serves 8
- Category: Main
- Method: Baking
- Cuisine: American
Ingredients
- 2 lbs lean ground beef
- 30 Ritz Crackers
- 2 cups milk
- 4 cups shredded mozzarella and cheddar cheese blend
- 10.5 oz condensed cheddar cheese soup
- 1 cup ketchup
- 1 cup Sweet Baby Ray's Hickory & Brown Sugar barbecue sauce
- 2 oz Lipton onion soup mix
- 2 eggs
- 3 cups macaroni noodles
- 1 teaspoon salt
- 1 teaspoon pepper
- 1 tablespoon garlic powder
- 1 tablespoon onion powder
Instructions
- Preheat your oven to 350°F (175°C).
- Mix ketchup and barbecue sauce in a bowl; set aside.
- Combine ground beef, crushed Ritz crackers, onion soup mix, eggs, and half of the ketchup mixture in a large bowl until well mixed.
- Transfer the meatloaf mixture to a greased baking dish; spread evenly and top with remaining ketchup mixture. Bake for 30 minutes.
- Cook macaroni according to package instructions; drain.
- In another bowl, whisk together milk, cheddar cheese soup, salt, pepper, garlic powder, and onion powder. Stir in cooked macaroni and half of the shredded cheese.
- Spread the macaroni mixture over the baked meatloaf; top with remaining cheese. Return to oven and bake for an additional 17-20 minutes until cheese is melted.
Nutrition
- Serving Size: Approximately 1 slice (200g)
- Calories: 450
- Sugar: 5g
- Sodium: 950mg
- Fat: 25g
- Saturated Fat: 12g
- Unsaturated Fat: 10g
- Trans Fat: 0g
- Carbohydrates: 35g
- Fiber: 2g
- Protein: 25g
- Cholesterol: 95mg
